Article
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.
BMC cancer - 19 Apr 2010
Feichtinger Rene' G, Zimmermann Franz, Mayr Johannes A, Neureiter Daniel, Hauser-Kronberger Cornelia, Schilling Freimut H, Jones Neil, Sperl Wolfgang, Kofler Barbara
Abstract excerpt
BACKGROUND: Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neuroblastoma tissue samples. METHODS: Spectrophotometric measurements, immunohistochemical analysis and Western blot analysis were used to characterize the aerobic mitochondrial energy metabolism...
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