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MITOCHONDRIA: Succinate dehydrogenase subunit B-associated phaeochromocytoma and paraganglioma.

The international journal of biochemistry & cell biology - 1 May 2021

Dona Margo, Neijman Kim, Timmers Henri J L M

Abstract excerpt

Phaeochromocytomas and paragangliomas are rare neuroendocrine tumours. So far, over 20 causative genes have been identified, of which the most frequent and strongest indicator for malignancies are mutations in succinate dehydrogenase subunit B. No curative therapy is available for patients with metastases resulting in poor prognosis. Therapy development has been hindered by lack of suitable model systems. The...

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PMID: 33609747
DOI: 10.1016/j.biocel.2021.105949

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