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Mitochondrial function and content in pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers

9 Feb 2012

Abstract excerpt

To date, the consequences of succinate dehydrogenase (SDH) impairment on overall mitochondrial functions are still obscure. In this study, we evaluated SDH activity and expression and mitochondrial homeostasis in 57 tissue samples of pheochromocytoma (PHEO)/paraganglioma (PGL) obtained from patients genotyped for PHEO/PGL susceptibility genes. The resulted SDH activity and content always decreased in SDH-mutated...

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PMID: 22323561
DOI: 10.1530/erc-11-0263

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