Article
Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2013
Rao Jyotsna U, Engelke Udo F H, Rodenburg Richard J T, Wevers Ron A, Pacak Karel, Eisenhofer Graeme, Qin Nan, Kusters Benno, Goudswaard Angelina G, Lenders Jacques W M, Hermus Ad R M M, Mensenkamp Arjen R, Kunst Henricus P M, Sweep Fred C G J, Timmers Henri J L M
Abstract excerpt
PURPOSE: Pheochromocytomas and paragangliomas (PGL) are neuroendocrine tumors of sympathetic and parasympathetic paraganglia. This study investigated the relationships between genotype-specific differences in mitochondrial function and catecholamine content in PGL tumors. EXPERIMENTAL DESIGN: Respiratory chain enzyme assays and (1)H-nuclear magnetic resonance (NMR) spectroscopy at 500 MHz were conducted on...
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