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Article

Rare variants contribute disproportionately to quantitative trait variation in yeast.

eLife - 24 Oct 2019

Bloom Joshua S, Boocock James, Treusch Sebastian, Sadhu Meru J, Day Laura, Oates-Barker Holly, Kruglyak Leonid

Abstract excerpt

How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the contributions of common and rare variants to quantitative traits. We generated ~14,000 progeny from crosses among 16 diverse yeast strains and identified thousands of quantitative trait loci (QTLs) for 38 traits. We combined our results with sequencing data for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Fungal

Share to High-Throughput Nucleotide Sequencing

Share to Quantitative Trait, Heritable

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Share to Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 31647408
DOI: 10.7554/eLife.49212
PMCID: PMC6892613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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