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Article

Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2010

Petrovsky Nadine, Quednow Boris B, Ettinger Ulrich, Schmechtig Anne, Mössner Rainald, Collier David A, Kühn Kai-Uwe, Maier Wolfgang, Wagner Michael, Kumari Veena

Abstract excerpt

Attentional gating deficits, commonly measured by prepulse inhibition (PPI) of the acoustic startle response (ASR), have been established as an endophenotype of schizophrenia. Prepulse inhibition is heritable and has been associated with polymorphisms in serotonin and dopamine system genes. Prepulse inhibition can be enhanced by nicotine, and therefore it has been proposed that schizophrenia patients smoke to...

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Source

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Identifiers

PMID: 20393456
DOI: 10.1038/npp.2010.12
PMCID: PMC3055462

Genes

CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.PMID 20393456Read ↗

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