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Article

Genetic variation of serotonin receptor function affects prepulse inhibition of the startle.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2009

Bräuer David, Strobel Alexander, Hensch Tilman, Diers Kersten, Lesch Klaus-Peter, Brocke Burkhard

Abstract excerpt

Prepulse inhibition (PPI) is the attenuation of the startle response towards an instantaneous and intense stimulus when preceded by a weaker non-startling stimulus. Deficits in this sensorimotor gating process have been associated with the pathophysiology of schizophrenia and other psychiatric disorders. Among the neurotransmitters involved in PPI modulation, serotonin (5-HT) has so far received comparably little...

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Source

Identifiers

PMID: 19352591
DOI: 10.1007/s00702-009-0222-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic variation of serotonin receptor function affects prepulse inhibition of the startle.PMID 19352591Read ↗

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Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats.Semantic proximity Read ↗

Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism.Semantic proximity Read ↗

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Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism.Semantic proximity Read ↗

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