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Article

The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 May 2011

Quednow Boris B, Ettinger Ulrich, Mössner Rainald, Rujescu Dan, Giegling Ina, Collier David A, Schmechtig Anne, Kühn Kai-Uwe, Möller Hans-Jürgen, Maier Wolfgang, Wagner Michael, Kumari Veena

Abstract excerpt

In a large-scale meta-analysis, it has been recently shown that the transcription factor 4 (TCF4) gene is among the most prominent susceptibility genes for schizophrenia. Moreover, transgenic mice overexpressing TCF4 in the brain display a reduction of sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR). PPI is heritable and has been established as an important...

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Identifiers

PMID: 21543597
DOI: 10.1523/JNEUROSCI.0526-11.2011
PMCID: PMC6632862

Genes

TCF4

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