The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism.

doi:10.1007/s00213-013-3081-1

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Article

The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism.

Psychopharmacology - 1 Sept 2013

Petrovsky Nadine, Ettinger Ulrich, Kessler Henrik, Mössner Rainald, Wolfsgruber Steffen, Dahmen Norbert, Maier Wolfgang, Wagner Michael, Quednow Boris B

Abstract excerpt

RATIONALE: Prepulse inhibition (PPI) of the acoustic startle response, a measure of sensorimotor gating, can be enhanced by nicotine. Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence. OBJECTIVES: We tested whether this CHRNA3 polymorphism also modulates the...

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PMID: 23604333
DOI: 10.1007/s00213-013-3081-1

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CHRNA3

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