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Article

Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.

Biological psychiatry - 1 Sept 2008

Quednow Boris B, Kühn Kai-Uwe, Mössner Rainald, Schwab Sibylle G, Schuhmacher Anna, Maier Wolfgang, Wagner Michael

Abstract excerpt

BACKGROUND: Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three...

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Source

Identifiers

PMID: 18420180
DOI: 10.1016/j.biopsych.2008.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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