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A human homologue of yeast anti‐silencing factor has histone chaperone activity

1 Mar 2000

Abstract excerpt

BACKGROUND: Structural changes in chromatin play essential roles in regulating eukaryotic gene expression. Silencing, potent repression of transcription in Saccharomyces cerevisiae, occurs near telomeres and at the silent mating-type loci, as well as at rDNA loci. This type of repression relates to the condensation of chromatin that occurs in the heterochromatin of multicellular organisms. Anti-silencing is a...

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PMID: 10759893
DOI: 10.1046/j.1365-2443.2000.00319.x

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