Article
Function analysis of a new type I PKS-SAT domain by SAT-EAT domain replacement.
Prikladnaia biokhimiia i mikrobiologiia - 1 Jan 2000
Jiao Y L, Wang L H, Jiao B H, Wang S J, Fang Y W, Liu S
Abstract excerpt
The function of a new starter unit acyltransferase (SAT) domain SAT-EF080951 (GenBank accession number) encoded in a new type I polyketide synthase (PKS) gene cluster EF568935 (GenBank accession number) isolated for this study was analyzed by domain replacement with an extender unit AT (EAT) domain of avermectin PKS. It was shown that the SAT-EF080951 incorporated malonyl-CoA specifically in vivo, which...
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