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Article

Engineering a Fungal Non-Reducing Polyketide Synthase with an Apparently Inactive Product-Template Domain Reveals Insights into the Catalytic Reprogramming.

International journal of molecular sciences - 18 Jun 2026

Yin Ruya, Qin Yifei, Liang Xingrui, Zhai Ziqi, Zhang Mengwei, Xu Dan, Zhou Ligang, Lai Daowan

Abstract excerpt

Fungal iterative non-reducing polyketide synthases (NR-PKS) contain a unique product template (PT) domain for aromatic cyclization. Among them, some NR-PKSs, such as the sorbicillin NR-PKS (SorB), have an apparently inactive PT. It is unknown what role such PT plays in NR-PKS programming. In this study, the PT domain of SorB was first dissected and engineered. Removal of the PT domain from SorB did not change the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42353248
DOI: 10.3390/ijms27125534
PMCID: PMC13300579

Genes

C2
C7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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