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An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain.

Angewandte Chemie (International ed. in English) - 8 May 2017

Xu Wei, Zhai Guifa, Liu Yuanzhen, Li Yuan, Shi Yanrong, Hong Kui, Hong Hui, Leadlay Peter F, Deng Zixin, Sun Yuhui

Abstract excerpt

Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis of the marginolactone azalomycin F in mangrove Streptomyces sp. 211726 has shown that only nineteen extension modules are required to accomplish twenty cycles of polyketide chain elongation. Analysis of the products of a PKS mutant specifically inactivated in the dehydratase domain of extension-module 1 showed that this...

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PMID: 28418225
DOI: 10.1002/anie.201701220
PMCID: PMC5518293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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