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Article

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

Journal of biotechnology - 10 Mar 2009

Xu Zhongli, Metsä-Ketelä Mikko, Hertweck Christian

Abstract excerpt

Benastatins are aromatic polyketides from Streptomyces spp. that efficiently inhibit glutathione-S-transferases and induce apoptosis. Their biosynthesis involves a type II polyketide synthase, and a ketoacyl synthase (KAS) III component (BenQ) similar to FabH that is crucial for providing and selecting the rare hexanoate PKS starter unit. The function of BenQ as a KAS III was experimentally proven by point...

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Identifiers

PMID: 19047004
DOI: 10.1016/j.jbiotec.2008.10.013

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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