Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

doi:10.1016/j.jbiotec.2008.10.013

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Article

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

Journal of biotechnology - 10 Mar 2009

Xu Zhongli, Metsä-Ketelä Mikko, Hertweck Christian

Abstract excerpt

Benastatins are aromatic polyketides from Streptomyces spp. that efficiently inhibit glutathione-S-transferases and induce apoptosis. Their biosynthesis involves a type II polyketide synthase, and a ketoacyl synthase (KAS) III component (BenQ) similar to FabH that is crucial for providing and selecting the rare hexanoate PKS starter unit. The function of BenQ as a KAS III was experimentally proven by point...

Topics

Acyltransferases
Antineoplastic Agents
Cysteine
Escherichia coli
Glutathione Transferase
Mutation
Naphthacenes
Naphthoquinones
Point Mutation
Polyketide Synthases
Protein Binding
Protein Engineering
Protein Subunits
Substrate Specificity

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PMID: 19047004
DOI: 10.1016/j.jbiotec.2008.10.013

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