Article
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Jez Joseph M, Bowman Marianne E, Noel Joseph P
Abstract excerpt
Type III polyketide synthases (PKS) generate an array of natural products by condensing multiple acetyl units derived from malonyl-CoA to thioester-linked starter molecules covalently bound in the PKS active site. One strategy adopted by Nature for increasing the functional diversity of these biosynthetic enzymes involves modifying polyketide assembly by altering the preference for starter molecules. Chalcone...
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