Prediction of inter domain interactions in modular polyketide synthases by docking and correlated mutation analysis.

Abstract excerpt

Polyketide synthases (PKSs) are huge multi-enzymatic protein complexes involved in the biosynthesis of one of the largest families of bioactive natural products, namely polyketides. The specificity of interactions between various catalytic domains of these megasynthases is one of the pivotal factors which control the precise order in which the extender units are joined during the biosynthetic process. Hence,...

Topics

• Acyl Carrier Protein
• Algorithms
• Binding Sites
• Catalytic Domain
• Models, Molecular
• Mutation
• Polyketide Synthases
• Polyketides
• Protein Conformation
• Protein Interaction Domains and Motifs