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Article

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.

Journal of neuroscience research - 1 Jul 2008

Lu Yi Wei, Tan Eng-King

Abstract excerpt

Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. The recent discovery of leucine-rich-repeat kinase 2 gene (LRRK2) mutations in PD is significant because these mutations are the most common cause of autosomal dominant PD. Furthermore, a common recurrent mutation (G2019S) is associated with a significant proportion of nonfamilial PD, and a polymorphic...

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Identifiers

PMID: 18338801
DOI: 10.1002/jnr.21656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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