Article
Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.
Journal of neuroscience research - 1 Jul 2008
Lu Yi Wei, Tan Eng-King
Abstract excerpt
Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. The recent discovery of leucine-rich-repeat kinase 2 gene (LRRK2) mutations in PD is significant because these mutations are the most common cause of autosomal dominant PD. Furthermore, a common recurrent mutation (G2019S) is associated with a significant proportion of nonfamilial PD, and a polymorphic...
Topics
- Cell Differentiation
- Cell Division
- Central Nervous System
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- Gene Expression Regulation
- Genes, Dominant
- Genetic Variation
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2