Article
Depletion of H2A-H2B dimers in Saccharomyces cerevisiae triggers meiotic arrest by reducing IME1 expression and activating the BUB2-dependent branch of the spindle checkpoint.
Genetics - 1 Aug 2003
Hanlon Sean E, Norris David N, Vershon Andrew K
Abstract excerpt
In the yeast Saccharomyces cerevisiae, diploid strains carrying homozygous hta1-htb1Delta mutations express histone H2A-H2B dimers at a lower level than do wild-type cells. Although this mutation has only minor effects on mitotic growth, it causes an arrest in sporulation prior to the first meiotic division. In this report, we show that the hta1-htb1Delta mutant exhibits reduced expression of early and...
Topics
- Cell Cycle Proteins
- DNA-Binding Proteins
- Dimerization
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Histones
- Homozygote
- Meiosis
- Mutation
- Nuclear Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Spindle Apparatus