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Article

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1991

Foiani M, Cigan A M, Paddon C J, Harashima S, Hinnebusch A G

Abstract excerpt

The GCD2 protein is a translational repressor of GCN4, the transcriptional activator of multiple amino acid biosynthetic genes in Saccharomyces cerevisiae. We present evidence that GCD2 has a general function in the initiation of protein synthesis in addition to its gene-specific role in translational control of GCN4 expression. Two temperature-sensitive lethal gcd2 mutations result in sensitivity to inhibitors...

Topics

Amino Acids
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factor-2B
Fungal Proteins
Genes, Fungal
Genotype
Kinetics
Leucine
Mutation
Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Polyribosomes

Protein Biosynthesis

Repressor Proteins

Ribosomes

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 2038326
DOI: 10.1128/mcb.11.6.3203-3216.1991
PMCID: PMC360173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2038326-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.PMID 2038326Read ↗

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.Semantic proximity Read ↗

A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.Semantic proximity Read ↗

Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.Semantic proximity Read ↗

Ssb2 is a novel factor in regulating synthesis and degradation of Gcn4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.Semantic proximity Read ↗

Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.Semantic proximity Read ↗

Conserved Function of Drg GTPases in Promoting Protein Synthesis in Stalled RibosomesSemantic proximity Read ↗

Conserved Function of Drg GTPases to Promote Protein Synthesis in the RibosomeSemantic proximity Read ↗

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