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Article

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1991

Foiani M, Cigan A M, Paddon C J, Harashima S, Hinnebusch A G

Abstract excerpt

The GCD2 protein is a translational repressor of GCN4, the transcriptional activator of multiple amino acid biosynthetic genes in Saccharomyces cerevisiae. We present evidence that GCD2 has a general function in the initiation of protein synthesis in addition to its gene-specific role in translational control of GCN4 expression. Two temperature-sensitive lethal gcd2 mutations result in sensitivity to inhibitors...

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Identifiers

PMID: 2038326
DOI: 10.1128/mcb.11.6.3203-3216.1991
PMCID: PMC360173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.PMID 2038326Read ↗

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GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Semantic proximity Read ↗

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Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.Semantic proximity Read ↗

A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling.Semantic proximity Read ↗

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Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.Semantic proximity Read ↗

Conserved Function of Drg GTPases in Promoting Protein Synthesis in Stalled RibosomesSemantic proximity Read ↗

Conserved Function of Drg GTPases to Promote Protein Synthesis in the RibosomeSemantic proximity Read ↗

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