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Article

Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae.

Genetics - 1 Mar 1998

Cuesta R, Hinnebusch A G, Tamame M

Abstract excerpt

In Saccharomyces cerevisiae, expression of the transcriptional activator GCN4 increases at the translational level in response to starvation for an amino acid. The products of multiple GCD genes are required for efficient repression of GCN4 mRNA translation under nonstarvation conditions. The majority of the known GCD genes encode subunits of the general translation initiation factor eIF-2 or eIF-2B. To identify...

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Identifiers

PMID: 9539420
DOI: 10.1093/genetics/148.3.1007
PMCID: PMC1460055

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae.PMID 9539420Read ↗

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Semantic proximity Read ↗

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.Semantic proximity Read ↗

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.Semantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.Semantic proximity Read ↗

GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.Semantic proximity Read ↗

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.Semantic proximity Read ↗

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast.Semantic proximity Read ↗

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