Article
Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.
Nucleic acids research - 1 Jul 2014
Ghosh Arnab, Jindal Supriya, Bentley Amber A, Hinnebusch Alan G, Komar Anton A
Abstract excerpt
Conserved ribosomal proteins frequently harbor additional segments in eukaryotes not found in bacteria, which could facilitate eukaryotic-specific reactions in the initiation phase of protein synthesis. Here we provide evidence showing that truncation of the N-terminal domain (NTD) of yeast Rps5 (absent in bacterial ortholog S7) impairs translation initiation, cell growth and induction of GCN4 mRNA translation in...
Topics
- Eukaryotic Initiation Factors
- Mutation
- Peptide Chain Initiation, Translational
- Protein Interaction Domains and Motifs
- Ribosomal Proteins
- Ribosomes
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins