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Article

Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.

Molecular and cellular biology - 1 Sept 2007

Martín-Marcos Pilar, Hinnebusch Alan G, Tamame Mercedes

Abstract excerpt

We identified a mutation in the 60S ribosomal protein L33A (rpl33a-G76R) that elicits derepression of GCN4 translation (Gcd- phenotype) by allowing scanning preinitiation complexes to bypass inhibitory upstream open reading frame 4 (uORF4) independently of prior uORF1 translation and reinitiation. At 37 degrees C, rpl33a-G76R confers defects in 60S biogenesis comparable to those produced by the deletion of RPL33A...

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Identifiers

PMID: 17548477
DOI: 10.1128/MCB.00019-07
PMCID: PMC1952170

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Source receipt: pubmed, retrieved 7 Sept 2026.

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