Article
Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.
Molecular and cellular biology - 1 May 1994
Vazquez de Aldana C R, Hinnebusch A G
Abstract excerpt
Phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) impairs translation initiation by inhibiting the guanine nucleotide exchange factor for eIF-2, known as eIF-2B. In Saccharomyces cerevisiae, phosphorylation of eIF-2 alpha by the protein kinase GCN2 s...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Eukaryotic Initiation Factor-2
- Eukaryotic Initiation Factor-2B
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Suppressor
- Genotype
- Guanine Nucleotide Exchange Factors
- Macromolecular Substances
- Mammals
- Molecular Sequence Data
- Mutagenesis