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Article

B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP).

PloS one - 1 Jan 2011

Schernhammer Eva S, Giovannucci Edward, Baba Yoshifumi, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: One-carbon metabolism appears to play an important role in DNA methylation reaction. Evidence suggests that a low intake of B vitamins or high alcohol consumption increases colorectal cancer risk. How one-carbon nutrients affect the CpG island methylator phenotype (CIMP) or BRAF mutation status in colon cancer remains uncertain. METHODS: Utilizing incident colon cancers in a large prospective cohort...

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Source

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Identifiers

PMID: 21738611
DOI: 10.1371/journal.pone.0021102
PMCID: PMC3124479

Genes

BRAF
CHFR
CRABP1
HIC1
IGF2
IGFBP3
MGMT
MLH1
NEUROG1
RUNX3
SOCS1
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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