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Article

The role of internal packing interactions in determining the structure and stability of a protein.

Journal of molecular biology - 20 May 1991

Lim W A, Sauer R T

Abstract excerpt

Cassette mutagenesis has been used to investigate how internal packing interactions help to specify a protein's three-dimensional structure and stability. Three interacting residues in the hydrophobic core of the N-terminal domain of lambda repressor were randomized combinatorially. The randomization was restricted to the five amino acids Val, Leu, Ile, Met and Phe, thereby generating a sterically diverse set of...

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Identifiers

PMID: 2038061
DOI: 10.1016/0022-2836(91)90570-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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