Functionally acceptable substitutions in two alpha-helical regions of lambda repressor.

doi:10.1002/prot.340070403

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Article

Functionally acceptable substitutions in two alpha-helical regions of lambda repressor.

Proteins - 1 Jan 1990

Reidhaar-Olson J F, Sauer R T

Abstract excerpt

A method of targeted random mutagenesis has been used to investigate the informational content of 25 residue positions in two alpha-helical regions of the N-terminal domain of lambda repressor. Examination of the functionally allowed sequences indicates that there is a wide range in tolerance to...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Escherichia coli
Membrane Proteins
Molecular Sequence Data
Monte Carlo Method
Mutation
Protein Conformation
Repressor Proteins
Transcription Factors
Viral Proteins
Viral Regulatory and Accessory Proteins

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