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Article

Exploiting elements of transcriptional machinery to enhance protein stability.

Journal of molecular biology - 9 Feb 2007

Barakat Nora H, Barakat Nesreen H, Carmody Lisa J, Love John J

Abstract excerpt

The correlation between protein structure and function is well established, yet the role stability/flexibility plays in protein function is being explored. Here, we describe an in vivo screen in which the thermal stability of a test protein is correlated directly to the transcriptional regulation of a reporter gene. The screen readout is independent of the function of the test protein, proteolytic resistance,...

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Identifiers

PMID: 17157872
DOI: 10.1016/j.jmb.2006.10.091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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