Article
Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.
Alimentary pharmacology & therapeutics - 1 Jul 2010
Tabernero D, Sánchez M J, Homs M, Rodríguez-Frías F, Jardí R, Schaper M, Esteban R, Buti M
Abstract excerpt
BACKGROUND: Some patients continue to have detectable HBV-DNA levels with liver disease progression after hepatitis B e antigen (HBeAg) loss. It is important to identify these patients, candidates for long-term treatment. AIMS: To evaluate hepatitis B virus (HBV) genotype and the main mutations in the basic core promoter (BCP, A1762T/G1764A) and precore (G1896A) sequences as markers of persistent HBV-DNA after...
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