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Article

Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.

PloS one - 1 Jan 2012

Kitab Bouchra, Essaid El Feydi Abdellah, Afifi Rajaa, Trepo Christian, Benazzouz Mustapha, Essamri Wafaa, Zoulim Fabien, Chemin Isabelle, Alj Hanane Salih, Ezzikouri Sayeh, Benjelloun Soumaya

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) is one of the most common human pathogens that cause aggressive hepatitis and advanced liver disease (AdLD), including liver cirrhosis and Hepatocellular Carcinoma. The persistence of active HBV replication and liver damage after the loss of hepatitis B e antigen (HBeAg) has been frequently associated with mutations in the pre-core (pre-C) and core promoter (CP) regions of HBV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22905181
DOI: 10.1371/journal.pone.0042891
PMCID: PMC3419231

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