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Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.

Hepatology (Baltimore, Md.) - 1 May 2021

Lau Daryl T Y, Ganova-Raeva Lilia, Wang Junyao, Mogul Douglas, Chung Raymond T, Lisker-Melman Mauricio, Chang Kyong-Mi, Shaikh Obaid S, Janssen Harry L A, Wahed Abdus S, Lok Anna S

Abstract excerpt

BACKGROUND AND AIMS: Hepatitis B virus (HBV) precore (PC) and dual basal core promoter (BCP) mutations halt and down-regulate hepatitis B e antigen (HBeAg) production respectively. PC mutation is rarely associated with HBV genotype A. We sought to examine the association of these variants with HBV genotypes, age, and HBeAg status in a racially diverse population in North America. Prospective study included 1,036...

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Identifiers

PMID: 32860463
DOI: 10.1002/hep.31506
PMCID: PMC8570313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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