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Mapping antibody-binding domains of the major outer surface membrane protein (OspA) of Borrelia burgdorferi

1 Jun 1991

Abstract excerpt

The major outer surface membrane protein of Borrelia burgdorferi, OspA, is one of several antigens recognized by sera from some patients in the chronic phase of Lyme borreliosis. We have expressed the OspA open reading frame in Escherichia coli and generated a series of deletion constructs of the gene and expressed them as trpE fusion proteins in E. coli. These constructs were used to identify antibody-binding...

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PMID: 2037351
DOI: 10.1128/iai.59.6.1911-1915.1991

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