Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

doi:10.1126/science.2237407

Article

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

26 Oct 1990

Abstract excerpt

Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi. The gene for outer surface protein A (OspA) from B. burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli. C3H/HeJ mice actively immunized with live transformed E. coli or purified recombinant OspA protein produced antibodies to OspA and were protected from challenge with several strains of B....

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