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Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A

15 Aug 2000

Abstract excerpt

Borrelia burgdorferi outer surface protein (Osp) A has been used as a Lyme disease vaccine that blocks transmission: OspA antibodies of immune hosts enter ticks during blood feeding and destroy spirochetes before transmission to the host can occur. B. burgdorferi produce OspA in the gut of unfed Ixodes scapularis ticks, and many spirochetes repress OspA production during the feeding process. This preferential...

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PMID: 10953031
DOI: 10.1172/jci9427

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