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Article

The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12.

Genomics - 1 Apr 1991

Davisson M T, Guay-Woodford L M, Harris H W, D'Eustachio P

Abstract excerpt

The mouse congenital polycystic kidney (cpk) mutation produces a condition that resembles human autosomal recessive polycystic kidney disease (ARPKD) in its pattern of inheritance, clinical progression, and histopathology. Inheritance of this mouse mutation in crosses segregating the Rb(12.14)8Rma translocation chromosome and various DNA markers of Chromosome 12 have localized cpk to a site near D12Nyu2,...

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Source

Identifiers

PMID: 2037305
DOI: 10.1016/0888-7543(91)90376-p

Genes

PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12.PMID 2037305Read ↗

The mouse congenital polycystic kidney (cpk) locus maps within 1.3 cM of the chromosome 12 marker D12Nyu2.Semantic proximity Read ↗

An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12.Semantic proximity Read ↗

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Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.Semantic proximity Read ↗

Somatic inactivation of Pkd2 results in polycystic kidney disease.Semantic proximity Read ↗

Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.Semantic proximity Read ↗

Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.Semantic proximity Read ↗

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Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats.Semantic proximity Read ↗

Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice.Semantic proximity Read ↗

Murine autosomal recessive polycystic kidney disease with multiorgan involvement induced by thecpk geneSemantic proximity Read ↗

Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic.Semantic proximity Read ↗

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