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Article

Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats.

The American journal of pathology - 1 Dec 2010

Neudecker Sabine, Walz Rebecca, Menon Kiran, Maier Elena, Bihoreau Marie-Therese, Obermüller Nicholas, Kränzlin Bettina, Gretz Norbert, Hoffmann Sigrid C

Abstract excerpt

The PKD/Mhm(cy/+) rat is a widely used animal model for the study of human autosomal dominant polycystic kidney disease, one of the most common genetic disorders, affecting one in 1000 individuals. We identified a new gene, Anks6, which is mutated (Anks6((p.R823W))) in PKD/Mhm(cy/+) rats. The evidence for a causal link between Anks6((p.R823W)) and cystogenesis is still lacking, and the function of Anks6 is...

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Identifiers

PMID: 21119215
DOI: 10.2353/ajpath.2010.100569
PMCID: PMC2993307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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