Murine autosomal recessive polycystic kidney disease with multiorgan involvement induced by thecpk gene

doi:10.1002/(sici)1097-0185(199607)245:3<488::aid-ar5>3.0.co;2-o

Article

Murine autosomal recessive polycystic kidney disease with multiorgan involvement induced by thecpk gene

1 Jul 1996

Abstract excerpt

BACKGROUND: Autosomal recessive (AR) polycystic kidney disease (PKD) is characterized in humans and mice as a rapidly progressive, collecting duct cystic disease usually leading to uremia in the neonatal or infantile period. In humans, ARPKD renal pathology can be variable in severity and is associated with the development of prominent bile duct and liver pathology. The C57BL/6J-cpk/cpk mouse model of ARPKD is...

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