Article
The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines.
Oncology reports - 1 May 2010
Mai Shi-Juan, Xie Dan, Huang Yu-Fan, Wang Feng-Wei, Liao Yi-Ji, Deng Hai-Xia, Liu Wen-Ju, Hua Wen-Feng, Zeng Yi-Xin
Abstract excerpt
The Epstein-Barr virus encoded nuclear antigen 1 (EBNA1) is required for the replication and maintenance of the episomal EBV genome and for the transactivation of viral gene expression. EBNA1 has been classified into five subtypes, among which the V-val subtype was reported to be associated with nasopharyngeal carcinoma (NPC). Here we report a higher transcriptional activity of the V-val subtype of EBNA1 than for...
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