Article
Sequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cells.
The Journal of general virology - 1 Jul 1997
Gutiérrez M I, Raj A, Spangler G, Sharma A, Hussain A, Judde J G, Tsao S W, Yuen P W, Joab I, Magrath I T, Bhatia K
Abstract excerpt
In seropositive individuals Epstein-Barr virus (EBV) establishes a virus reservoir in peripheral blood lymphocytes (PBLs). Transmission from one individual to another occurs via saliva due to a lytic (virion productive) phase of infection in the oropharynx. EBNA-1 is responsible for maintaining v...
Topics
- Amino Acid Sequence
- Cells, Cultured
- Epstein-Barr Virus Nuclear Antigens
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- Lymphocytes
- Molecular Sequence Data
- Nasopharyngeal Neoplasms
- Saliva
- Tissue Distribution
- Tumor Cells, Cultured