Article
Functional advantage of NPC-related V-val subtype of Epstein-Barr virus nuclear antigen 1 compared with prototype in epithelial cell line.
Oncology reports - 1 Jan 2007
Mai Shi-Juan, Ooka Tadamasa, Li Da-Jiang, Zeng Mu-Sheng, Jiang Ri-Cheng, Yu Xing-Juan, Zhang Ru-Hua, Chen Shi-Ping, Zeng Yi-Xin
Abstract excerpt
Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC) and the viral nuclear antigen 1 (EBNA1) plays a crucial role in viral latency. Three EBNA1 subtypes, P-ala, V-thr and V-val have been detected from healthy carriers in Guangzhou area. A close relation of V-val EBNA1 with NPC was suggested by its preference to infect NPC cells. We therefore investigated the functional difference...
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