Article
A major EBNA1 variant from Asian EBV isolates shows enhanced transcriptional activity compared to prototype B95.8.
Virus research - 1 Mar 2008
Do Nguyen-Van, Ingemar Ernberg, Phi Phan-Thi Phi, Jenny Almqvist, Chinh Tran-Thi, Zeng Yixin, Hu Lifu
Abstract excerpt
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) has an instrumental role in maintaining EBV latent infection by controlling EBV episome replication and regulating viral transcription. It is a ubiquitously expressed protein during latent viral infection and in EBV-associated tumors. The EBNA1 C-terminus interacts functionally with the Qp and Cp that control viral gene expression in latency I/II and III,...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Cell Line
- China
- Epstein-Barr Virus Infections
- Epstein-Barr Virus Nuclear Antigens
- Genes, Reporter
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- Mutation
- Nasopharyngeal Neoplasms