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Article

Limited sequence heterogeneity of Epstein-Barr virus nuclear antigen 1 in benign and malignant EBV-associated disorders.

Infection - 1 Jan 2000

Schuster V, Ott G, Seidenspinner S, Kreth H W

Abstract excerpt

BACKGROUND: The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) is essential for replication and maintenance of circular EBV genomes in latently infected B lymphocytes and is the only EBV protein expressed in nearly all cells carrying the virus. EBNA-1 is suggested to be oncogenic in vivo since its expression induces B-cell neoplasia in transgenic mice. PATIENTS, MATERIALS AND METHODS: EBV wild-type isolates...

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Identifiers

PMID: 10879636
DOI: 10.1007/s150100050066

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Source receipt: pubmed, retrieved 7 Sept 2026.

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