Article
A sequence variant on 17q21 is associated with age at onset and severity of asthma.
European journal of human genetics : EJHG - 1 Aug 2010
Halapi Eva, Gudbjartsson Daniel F, Jonsdottir Gudrun M, Bjornsdottir Unnur S, Thorleifsson Gudmar, Helgadottir Hafdis, Williams Carolyn, Koppelman Gerard H, Heinzmann Andrea, Boezen H Marike, Jonasdottir Aslaug, Blondal Thorarinn, Gudjonsson Sigurjon A, Jonasdottir Adalbjorg, Thorlacius Theodora, Henry Amanda P, Altmueller Janine, Krueger Marcus, Shin Hyoung Doo, Uh Soo-Taek, Cheong Hyun Sub, Jonsdottir Brynja, Ludviksson Bjorn R, Ludviksdottir Dora, Gislason David, Park Choon-Sik, Deichmann Klaus, Thompson Philip J, Wjst Matthias, Hall Ian P, Postma Dirkje S, Gislason Thorarinn, Kong Augustine, Jonsdottir Ingileif, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was recently found to be associated with childhood asthma. We sought to evaluate the effect of rs7216389-T on asthma subphenotypes and its correlation with expression levels of neighboring genes. The association of rs721638...
Read the complete abstract on PubMed