Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.

doi:10.1164/rccm.202006-2623OC

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Article

Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.

American journal of respiratory and critical care medicine - 15 Feb 2021

Gui Hongsheng, Levin Albert M, Hu Donglei, Sleiman Patrick, Xiao Shujie, Mak Angel C Y, Yang Mao, Barczak Andrea J, Huntsman Scott, Eng Celeste, Hochstadt Samantha, Zhang Ellen, Whitehouse Kyle, Simons Samantha, Cabral Whitney, Takriti Sami, Abecasis Gonçalo, Blackwell Thomas W, Kang Hyun Min, Nickerson Deborah A, Germer Soren, Lanfear David E, Gilliland Frank, Gauderman W James, Kumar Rajesh, Erle David J, Martinez Fernando D, Hakonarson Hakon, Burchard Esteban G, Williams L Keoki

Abstract excerpt

Rationale: The 17q12-21.1 locus is one of the most highly replicated genetic associations with asthma. Individuals of African descent have lower linkage disequilibrium in this region, which could facilitate identifying causal variants.Objectives: To identify functional variants at 17q12-21.1 associated with early-onset asthma among African American individuals.Methods: We evaluated African American participants...

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Identifiers

PMID: 32966749
DOI: 10.1164/rccm.202006-2623OC
PMCID: PMC7885840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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