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Article

Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

PLoS genetics - 1 Apr 2010

Nica Alexandra C, Montgomery Stephen B, Dimas Antigone S, Stranger Barbara E, Beazley Claude, Barroso Inês, Dermitzakis Emmanouil T

Abstract excerpt

The recent success of genome-wide association studies (GWAS) is now followed by the challenge to determine how the reported susceptibility variants mediate complex traits and diseases. Expression quantitative trait loci (eQTLs) have been implicated in disease associations through overlaps between eQTLs and GWAS signals. However, the abundance of eQTLs and the strong correlation structure (LD) in the genome make...

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Identifiers

PMID: 20369022
DOI: 10.1371/journal.pgen.1000895
PMCID: PMC2848550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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