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Article

Estimating the causal tissues for complex traits and diseases.

Nature genetics - 1 Dec 2017

Ongen Halit, Brown Andrew A, Delaneau Olivier, Panousis Nikolaos I, Nica Alexandra C, Dermitzakis Emmanouil T

Abstract excerpt

How to interpret the biological causes underlying the predisposing markers identified through genome-wide association studies (GWAS) remains an open question. One direct and powerful way to assess the genetic causality behind GWAS is through analysis of expression quantitative trait loci (eQTLs). Here we describe a new approach to estimate the tissues behind the genetic causality of a variety of GWAS traits,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29058715
DOI: 10.1038/ng.3981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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