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Article

Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer.

The pharmacogenomics journal - 1 Apr 2011

Pohl A, Azuma M, Zhang W, Yang D, Ning Y, Winder T, Danenberg K, Lenz H-J

Abstract excerpt

Aurora kinases are conserved eukaryotic serine-threonine kinases, which serve as key regulators of mammalian mitosis. Several studies revealed a distinct correlation between inaccurate chromosome segregation, leading to chromosomal number instability, cancer progression and poor outcome. The aim of this study was to investigate the correlation of Aurora kinases A (AURKA) and B (AURKB) with overall survival (OS)...

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Source

Identifiers

PMID: 20368716
DOI: 10.1038/tpj.2010.18

Genes

AURKB
AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer.PMID 20368716Read ↗

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Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read ↗

Aurora-A Kinase as a Promising Therapeutic Target in CancerSemantic proximity Read ↗

Aurka orchestrates colorectal cancer progression through dual regulation of tumor proliferation and immune microenvironmentSemantic proximity Read ↗

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