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Article

Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.

Scientific reports - 31 Aug 2021

Mesic Aner, Rogar Marija, Hudler Petra, Bilalovic Nurija, Eminovic Izet, Komel Radovan

Abstract excerpt

Glioblastoma multiforme (GBM) is the most frequent type of primary astrocytomas. We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC) and Polo-like kinase 1 (PLK1) mitotic checkpoint genes and GBM risk by qPCR genotyping. In silico analysis was performed to evaluate effects of polymorphic biological sequences on...

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Identifiers

PMID: 34465813
DOI: 10.1038/s41598-021-96935-y
PMCID: PMC8408269

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