Article

Aurka orchestrates colorectal cancer progression through dual regulation of tumor proliferation and immune microenvironment

2025-07-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The third most common malignancy globally, colorectal cancer (CRC), remains the leading cause of cancer-related mortality despite significant therapeutic advancements. Aurora Kinase A (AURKA) functions as a key molecular hub, influencing both its canonical role in cell proliferation and its modulation of the tumor microenvironment (TME). Although its dual roles...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d0ef142-112c-5789-80f5-3c8a3af1678c
DOI: 10.21203/rs.3.rs-7001456/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aurka orchestrates colorectal cancer progression through dual regulation of tumor proliferation and immune microenvironmentDOI 10.21203/rs.3.rs-7001456/v1Read

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal CancerSemantic proximity Read

Aurora Kinase A (AURKA) Regulates The Progression and Imatinib Resistance of Advanced Gastrointestinal Stromal TumorsSemantic proximity Read

Identification and Validation of Aurora Kinase A (AURKA) Involved in the Progression and Imatinib Resistance of Advanced Gastrointestinal Stromal TumorsSemantic proximity Read

Aurora kinase A in gastrointestinal cancers: time to targetSemantic proximity Read

Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious DiseasesSemantic proximity Read

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity Read

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expressionSemantic proximity Read

An analysis of AURKB's prognostic and immunological roles across various cancers.Semantic proximity Read

Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinomaSemantic proximity Read

ARID3A promotes the development of colorectal cancer by upregulating AURKASemantic proximity Read

The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal CarcinomasSemantic proximity Read

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinomaSemantic proximity Read