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Article

N-terminal regions of Mps1 kinase determine functional bifurcation.

The Journal of cell biology - 5 Apr 2010

Araki Yasuhiro, Gombos Linda, Migueleti Suellen P S, Sivashanmugam Lavanya, Antony Claude, Schiebel Elmar

Abstract excerpt

Mps1 is a conserved kinase that in budding yeast functions in duplication of the spindle pole body (SPB), spindle checkpoint activation, and kinetochore biorientation. The identity of Mps1 targets and the subdomains that convey specificity remain largely unexplored. Using a novel combination of systematic deletion analysis and chemical biology, we identified two regions within the N terminus of Mps1 that are...

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Identifiers

PMID: 20368617
DOI: 10.1083/jcb.200910027
PMCID: PMC2854372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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